We have simulated 10-residue polyalanine chain by multicanonical method tovisualize the 3D topographic picture of the free energy landscape over thewhole range of temperatures, hence to show the funnel along the folding pathwayexhaustively. We have simulated and compared the system in vacuo and insolvent, and examined the changes in the free energy landscape due to thesolvent effects, which are taken into account by commonly used model AccessibleSurface Area.
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